Macrophages and Uveitis in Experimental Animal Models

In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis

Purpose We develop a quantitative bioluminescence assay for in vivo longitudinal monitoring of inflammation in animal models of uveitis. Methods Three models of experimental uveitis were induced in C57BL/6 albino mice: primed mycobacterial uveitis (PMU), endotoxin-induced uveitis (EIU), and experimental autoimmune uveitis (EAU). Intraperitoneal injection of luminol sodium salt, which emits li...

Animal models of autoimmune and immune-mediated uveitis

Uveitis of putative autoimmune origin comprises a heterogeneous group of sight-threatening diseases prevalent in the US and worldwide. Several animal models, representing various forms of uveitis, have been developed. These models reproduce distinct aspects of human disease and can serve to study basic mechanisms and as templates for therapy. ‘Humanized’ models have recently become available th...

Autoimmune Uveitis RANTES to Suppress Experimental Macrophages: The Macrophages Produce Immunoregulatory Role of Ocular

Intra-vitreal injection of methotrexate in experimental endotoxin-induced uveitis in rabbit

Uveitis is a major cause of vision loss. Methotrexate (MTX) has been widely used in uveitis due to its relatively safe profile. The purpose of this study was to evaluate the effects of two different dosages of MTX via intra-vitreal administration for treatment of endotoxin induced uveitis (EIU) in an experimental model. Thirty-five healthy rabbits were randomly divided into four groups and all ...

Evaluation of intravitreal injection of pentoxifylline in experimental endotoxin-induced uveitis in rabbits

The objective of the present study was to investigate the clinical and histopathological effects of intravitreal injection of pentoxifylline (PTX) the management of an experimental model of uveitis. Fifty-two rabbits were divided randomly into six intravitreal treated groups as below: 1) Balanced salt solution (BSS), 2) Salmonella typhimurium lipopolysaccharide endotoxin (LPS) + BSS, 3...